The number of people worldwide who have died with Covid-19 has passed one million, researchers say, with many regions still reporting surging numbers of new infections.
The tally by Johns Hopkins University shows that deaths in the US, Brazil and India make up nearly half that total.
Experts caution that the true figure is probably much higher.
UN Secretary-General António Guterres called it a “mind-numbing” figure and “an agonising milestone”.
“Yet we must never lose sight of each and every individual life,” he said in a video message.
“They were fathers and mothers, wives and husbands, brothers and sisters, friends and colleagues. The pain has been multiplied by the savageness of this disease.”
The development comes nearly 10 months after news of the coronavirus began to emerge from Wuhan, China.
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The pandemic has since spread to 188 countries with more than 32 million confirmed cases. Lockdowns and other measures to try to stop the virus spreading have thrown many economies into recession.
Meanwhile, efforts to develop an effective vaccine are continuing – although the World Health Organization (WHO) has warned that the death toll could hit two million before one is widely available.
The US has the world’s highest death toll with about 205,000 fatalities followed by Brazil on 141,700 and India with 95,500 deaths.
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The US has recorded more than seven million cases – more than a fifth of the world’s total. After a second wave of cases in July, numbers dropped in August but appear to be on the rise again now.
The coronavirus has been spreading fast in India, with the country recording about 90,000 cases a day earlier in September.
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Confirmed infections in India have reached six million – the second-highest after the US. However, given the size of its population India has seen a relatively low death rate.
Brazil has the highest number of deaths in Latin America and has recorded more than 4.7 million cases, the third highest in the world.
Elsewhere in the region, newly confirmed infections are also rising quickly in Argentina, which now has more than 700,000 cases.
Age and climate seen as behind Africa’s low cases
Latest tallies show that nearly 1.5 million people in Africa have been confirmed as contracting coronavirus, with around 35,000 deaths.
Younger, less dense populations and hot, humid climates are being cited as key reasons why the continent has been spared a higher number of cases. The WHO has also praised the “decisive” action by African nations.
Because of differences in how countries record cases and deaths – and the sporadic rates of testing in some regions – the true numbers of coronavirus cases and deaths is believed to be higher than reported, experts say.